PET and Mass Spectrometry Experience

I am a grad student with PET and Mass spectrometry experience. Just wanted to dabble a little bit with NMR analyzer to further my postdoc .
Good side :
1.Very thorough. Everything is explained in great detail. You don’t need to have a very good math background to begin with.
2.figures are great and carefully drawn. They assisted my understanding greatly.
3.No buzz words, no weird comparisons. The “English” is very easy to understand.
Bad side :
1. Did not stimulate much of the critical thinking, lacks real life case studies
2. A little bit too lengthy in words. After reading the first two chapters, I started to skip words but only focused on figures and italic comments, and it worked better for me.
3. No answers for the exercise problems. The problems are not too hard though.

Keeler’s book is a very clear exposition of the physical basis and quantum mechanical underpinnings of modern NMR experiments. Because it is fundamentally based on the quantum mechanics, it is, I feel, a better introduction to heteronuclear NMR than the popular book by Claridge. At the same time, Keeler avoids the dense pages of mathematics that can make Cavanagh et al.’s excellent book intimidating to students who are not experts on quantum mechanics. An additional plus for me was Keeler’s refreshingly clear description of the physical origins of T2 relaxation.

At the same time, there are some deficiencies here. Keeler does not go into chemical exchange effects in any depth, and I do not believe he mentions REX at all. There is also no discussion of residual dipolar couplings, the model-free dynamics formalism, or diffusion experiments. Pulsed-field gradients and phase-cycling are presented almost as an afterthought. The discusisons of coherence order and raising/lowering operators leave something to be desired and the later chapters in which they appear are structured awkwardly. Keeler deals exclusively with dipolar systems in liquids, limitations that may make this text inappropriate for some labs.

That said, for someone who’s had some exposure to NMR (in, say, an organic chemistry course) this is an excellent, clear tour of some theoretical NMR basics that can provide a useful framework for approaching more comprehensive texts. Graduate students without a stong background in physical chemistry who intend to perform advanced work in NMR may find this book particularly helpful.


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