Applications of NMR Spectroscopy

Applications of NMR Spectroscopy, Volume 1, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of edible oils and lipid content in foods, the role of NMR spectroscopy in the human metabolomics and the diagnosis of autism-related disorders, protein-protein interactions, and NMR spectroscopy of chiral molecules.

The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications.

The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.

Consolidates the latest developments in NMR spectroscopy into a single volume
Authored and edited by world-leading experts in spectroscopy
Features comprehensive references to the most recent related literature
More than 75 illustrations aid in the retention of key concepts

PQ001 Oil Moisture Content NMR Analyzer for Seeds

Product Description
The PQ001 NMR Analyzer was launched in 2008. After years of upgrading, PQ001 has many advantages such as small size, high precision, good repeatability, good stability and excellent cost/benefit performance. Based on these advantages, PQ001 has been widely used in the determination of oil & moisture content in food & agriculture areas.

Basic Parameters
  • Magnet type: permanent magnet
  • Magnetic field intensity: 0.28±0.05T
  • Probe coil: Ø40mm
  • Size (LxWxH): 1685mm×520mm×386mm
  • Weight: 85Kg

pq00112

Flow and Diffusion Measurement with MR

Nuclear magnetic resonance (NMR) non-invasively accesses many parameters in contrast with other commonly used measurement methods, whether they are non-invasive or not.
These parameters can be divided roughly into three classes of information: chemical, physical, and spatial.Chemical includes benchtop NMR spectroscopy, the workhorse in analytical chemistry and in structural biochemistry but, to date, there has been relatively little overlap between this class and this conference.
Physical information accessible with NMR analyzer includes molecular structure, phase transition, diffusion, and flow.Both chemical and physical information can be combined with spatial information to produce maps of such information.In addition, flow and diffusion, by their nature, involve spatial information.
Such spatially resolved information is the main emphasis of this meeting.In this lecture, I shall review NMR flow and diffusion measurements.What is needed for such measurements is the presence of a known gradient of the static magnetic field strength in which the experiments are conducted.
When a nuclear spin moves in the field gradient, its precession rate changes and this can be detected to yield the displacement of the spin in the time required to do the experiment–times measured in milliseconds.The dependence of such displacements as a function of measurement time results in identification of the nature of sample motion, i. e., whether it is flow or diffusion.
We will start with basic principles and go on to examples with emphasis on gaining physical background knowledge that may aid in understanding flow and diffusion presentations during this meeting.Some references to this subject are listed below.The last three are based on previous ICMRM conferences, specifically in 1991, 1997, and 2009.

Mobile NMR

Mobile NMR started in the well logging industry. Early on, benchtop NMR devices were developed to be deployed inside the borehole to characterize the fluids of the well downhole [1]. The successful NMR analyzer well-logging devices measure distributions of relaxation and diffusion parameters in the stray field of permanent magnets .

The same principle is followed with the much smaller NMR-MOUSE , which has a higher field, a stronger gradient, and a smaller sensitive volume. It is used for nondestructive materials testing of large objects such as rubber tires, polymer pipes, and objects of art . Today, the NMR force microscope is the smallest stray-field NMR device .

While the sensitive volume of stray-field NMR devices can be shaped with proper magnet design , the sensitivity can significantly be improved only by enlarging the sensitive volume and the field strength, a strategy which returns mobile NMR to the roots of NMR spectroscopy and imaging with closed magnets.

In fact, a variety of desktop MRI magnets has been pioneered by Kose , and the first miniature spectroscopy magnet has been developed by McDowell . Today miniature NMR gadgets are targeted for specific detection of biomarkers , and the first desktop NMR spectrometers for chemical analysis by high-resolution NMR appear on the market .

The advances in mobile NMR are expected to benefit from the progress in developing widely applicable and miniaturized hyperpolarization methodologies, alternative detection schemes, microfluidic components for sample preparation and handling, the use of high-TC superconducting magnets, and the development of user-friendly apps for different types of information-driven measurements by untrained NMR consumers.

Solid State NMR Spectroscopy: Principles and Applications

This book is for those familiar with solution-state benchtop NMR who are encountering solid-state NMR for the first time. It presents the current understanding and applications of solid-state NMR with a rigorous but readable approach, making it easy for someone who merely wishes to gain an overall impression of the subject without details. This dual requirement is met through careful construction of the material within each chapter.
The book is divided into two parts: “Fundamentals” and “Further Applications.” The section on Fundamentals contains relatively long chapters that deal with the basic theory and practice of solid-state NMR. The essential differences and extra scope of solid-state NMR over solution-state is dealt with in an introductory chapter. The basic techniques that all chapters rely on are collected into a second chapter to avoid unnecessary repetition later. Remaining chapters in the “Fundamentals” part deal with the major areas of solid-state NMR which all solid-state NMR spectroscopists should know about. Each begins with an overview of the topic that puts the chapter in context.

The basic principles upon which the techniques in the chapter rely are explained in a separate section. Each of these chapters exemplifies the principles and techniques with the applications most commonly found in current practice.

The “Further Applications” section contains a series of shorter chapters which describe the NMR analyzer techniques used in other, more specific areas. The basic principles upon which these techniques rely will be expounded only if not already in the Fundamentals part.

This book presents the current understanding and applications of solid-state NMR. The rigorous, but readable approach makes it easy for someone who wishes to gain an overall impression of the subject or get into the details.

The book is divided into two parts: “Fundamentals” and “Applications”. The section on Fundamentals contains chapters that deal with the basic theory and practice of solid-state NMR. The basic techniques which all chapters rely on are collected into a second chapter to avoid unnecessary repetition later. Remaining chapters in the “Fundamentals” part deal with the major areas of solid-state NMR. Each begins with an overview of the topic which sets the chapter in context. Each of these chapters exemplifies the principles and techniques with the applications most commonly found in current practice.

The “Applications” section contains a series of shorter chapters which describe the NMR techniques used in specific areas of chemistry, biochemistry and material science. These chapters include detailed discussion of what solid-state NMR spectroscopy can tell scientists about problems of current interest in these areas.
Solid-state NMR Spectroscopy: Principles and Applications will be useful to all those in the fields of analytical chemistry and chemical technology both in the chemical and allied industries and in academic and government laboratories.

NMR Spectroscopy Explained

This is the best all around benchtop NMR text I have come across. Jacobsen does a great job of explaining the vast array of topics in NMR ranging from the nuclear magnetism and pulse sequences to biological NMR. It is very well written, easy to read and follow, while still going into great amounts of detail.

For those who do not enjoy heavy amounts of differential equations and linear algebra, then you will appreciate this book as there is just enough math to aid the written explanations, but not so much as to make your head spin. This book also has one of the best explanations/discussions on multi-dimensional techniques commonly used in organic and biological chemistry.

There is one specific area where I find this book is somewhat lacking, the discussion on T1, T2 and NOE which is fairly rudimentary. It is more than sufficient for those new to the topic or working on small molecules, but does not offer much past that in my opinion. Also, if you are looking for a better understanding in solid state NMR, this is not the book for you. I would highly recommend this book for anyone wanting to learn more about NMR analyzer.

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments.
Introduces students to modern NMR as applied to analysis of organic compounds.
Presents material in a clear, conversational style that is appealing to students.
Contains comprehensive coverage of how NMR experiments actually work.
Combines basic ideas with practical implementation of the spectrometer.
Provides an intermediate level theoretical basis for understanding laboratory experiments.
Develops concepts gradually within the context of examples and useful experiments.
Introduces the product operator formalism after introducing the simpler (but limited) vector model.

Initially I wanted to write a review for this book after I finish the whole book. However, since the publication of this book, I have noticed that nobody has ever written a review. I have only finished approximately 400 pages but I want to let people to know that this is clearest exposition on modern nmr spectroscopy I have ever come across. I have read a number of nmr books. These include the following

J.D. Roberts “ABC of FT NMR”
T. Claridge “High Resolution NMR spectroscopy in organic chemistry”
J. Sanders ” Modern NMR spectroscopy”
H. Friebolin “Basic One- and Two-Dimenionsal NMR”

None of the above is as good as this book. The one that comes close to this is Friebolin’s book. However, it is not as detail and does not cover topics such as operator formalism and density matrix. This book also covers the basic theoretical principles and presented in a very lucid way. I enjoy reading this book tremendously.

Dec 14, 2009. It has been almost 2 years since I wrote the initial review. Since then, I have the opportunity to read the whole book a second time. My opinion of this book remains the same. If you really want to understand NMR, you cannot go wrong with this book.

Structural Biology: Practical NMR Applications

This is an impressive and detailed book for anyone who wants to know NMR analyzer. I found in this book all what I need about protein NMR from basic level up to most advanced triple-resonance experiments. This textbook (or reference book) is helpful for all levels of students and experts. After reading through the book, I feel like I am an NMR expert because the book not only teaches the new thing I did not know but also summarizes what I already knew. I showed it to my friends and they all like it just by looking at the table of contents. I totally agree with the reviewer’s comments printed on the book cover:

“This is the first totally thorough book on the subject…” by Lawrence J. Berliner, University of Denver

“While NMR treatises abound, there exists no single text that provides both the information necessary to understand the experiments and processes, as well as the practical details for their successful implementation. This considerable gap in the literature is now happily bridged by Quincy Teng’s timely contribution.” By Gerd N. La Mar, University of California, Davis.

This book clearly illustrates the major aspects of NMR spectroscopy, instrumentation and applications in a relatively simple language without the use of complicated mathematics. The questions at the end of each section reflect the main points of the contents. It can be used as a self study textbook for beginners, as well as a reference for teaching and research in NMR spectroscopy.

This textbook begins with an overview of benchtop NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

This is the first totally through book on the subject. It covers theory, the instrument, how to run an experiment, the latest in pulse and structure determination methods. The best part is that it’s written as a textbook with questions and goal at the beginning of each section and homework or exam problems. It is ideal for a graduate or advanced undergraduate course on biological NMR.” – Lawrence J. Berliner, University of Denver, Denver, CO, USA “While NMR treatises abound, there exists no single text that provides both the information necessary to understand the experiments and processes, as well as the practical details for their successful implementation. This considerable gap in the literature is now happily bridged by Quincy Teng’s timely contribution. – Gerd N. La Mar, University of California, Davis, CA, USA

Multidimensional Solid-State NMR and Polymers

NMR spectroscopy is the most valuable and versatile analytical tool in chemistry. While excellent monographs exist on high-resolution NMR in liquids and solids, this is the first book to address multidimensional solid-state NMR. Multidimensional techniques enable researchers to obtain detailed information about the structure, dynamics, orientation, and phase separation of solids, which provides the basis of a better understanding of materials properties on the molecular level.Dramatic progress-much of it pioneered by the authors-has been achieved in this area, especially in synthetic polymers.

Solid-state benchtop NMR now favorably competes with well-established techniques, such as light, x-ray, or neutron scattering, electron microscopy, and dielectric and mechanical relaxation.
The application of multidimensional solid-state NMR analyzer inevitably involves use of concepts from different fields of science. This book also provides the first comprehensive treatment of both the new experimental techniques and the theoretical concepts needed in more complex data analysis.

The text addresses spectroscopists and polymer scientists by treating the subject on different levels; descriptive, technical, and mathematical approaches are used when appropriate. It presents an overview of new developments with numerous experimental examples and illustrations, which will appeal to readers interested in both the information content as well as the potential of solid-state NMR.

The book also contains many previously unpublished details that will be appreciated by those who want to perform the experiments. The techniques described are applicable not only to the study of synthetic polymers but to numerous problems in solid-state physics, chemistry, materials science, and biophysics.

Key Features
* Presents original theories and new perspectives on scattering techniques
* Provides a systematic treatment of the whole subject
* Gives readers access to previously unpublished material
* Includes extensive illustrations
One of the best books on solid-state NMR currently published. The authors present a thorough overview of theory of solids NMR with the focus on applications in polymer science. Would be one of my first choices for a graduate level textbook in solid-state NMR. Targeted at an intermediate reader familiar with the basic concepts of NMR. Highly recommended

Definitely a very comprehensive textbook which treats many relevant and modern advances in the field. A must-have for every researcher in solid state NMR. Downside is that the book is written in the style of a reference book, and not really good as teaching material. But overall I give it 4 stars. Michael Mehring’s book on solid state nmr is still the best teaching manual to learn the theory.